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In a Nutshell
Cholestyramine, originally a cholesterol-lowering drug, binds bile acids to deplete liver cholesterol, upregulating the cholesterol synthesis pathway that also produces vital mitochondrial components coenzyme Q10 and heme A, enhancing energy production and aiding mold toxin removal. Unlike statins, it ramps up cholesterol synthesis, but requires gradual dosing to avoid acute deficits in cellular membranes and mitochondrial function. High-performers are prone to chronic illnesses like long COVID, Lyme, and mold due to stress-accelerated mitochondrial decline (1% yearly with age), which drains the body's energy budget and triggers repair failure cycles.
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Cholestyramine was originally a cholesterol-lowering drug used in the 1984 clinical trial considered proof that cholesterol causes heart disease. It works by binding bile acids and causing their excretion. Bile acids are made from cholesterol, so when bile acids are removed, the liver lacks cholesterol and takes it from the blood while increasing its own synthesis. Unlike statins, cholestyramine ramps up the liver's cholesterol synthesis.
Speaker built a mold filter 20 years ago using a 25-inch box fan, MERV 11 filter from Home Depot, and packing tape, based on Shoemaker's books. In the cholesterol synthesis pathway, two essential mitochondrial components are produced: coenzyme Q10 and heme A (component of the last mitochondrial engine for ATP production). Cholestyramine helps remove mycotoxins (mitochondrial toxins) per Shoemaker, but also boosts these mitochondrial components independently by upregulating the pathway.
The cholesterol synthesis pathway has 30-40 steps with branches producing multiple products, including cholesterol, coenzyme Q10, and heme A. Drugs act early in the pathway, affecting all downstream products. Depleting cholesterol prompts the liver to ramp up the pathway (increasing those products) and pull cholesterol from blood. The 1984 trial focused on blood cholesterol reduction; Shoemaker on toxin excretion via bile; additionally, it improves mitochondrial machinery.
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