EP231: Lipid Biology, Plasmalogens, and Neurodegenerative Prodromes - Part 2 - Dayan Goodenowe, PhD
In a Nutshell
Dr. Dayan Goodenowe explains chronic diseases (autism, Alzheimer's, MS, Parkinson's, ALS, Long COVID, ME-CFS) as acquired losses of biochemical resilience due to entropy, mitochondrial/peroxisomal dysfunction, and plasmalogen deficiencies, detectable via prodromes like low HDL (<50-60), total cholesterol (<200), high triglycerides (>100), and elevated homocysteine. Restoration prioritizes plasmalogen precursors (omega-3 for gray matter/synapses, omega-9 for white matter), phosphocholine from animal sources, methyltransferase support (B12, methylfolate, TMG, NAC), niacin for NAD, and mitochondrial boosters (carnitine, acetylcysteine) over toxin removal alone, reversing neurodegeneration, improving brain structure/function, and building adaptability. Daily practices include resistance training, hormetic stress, purpose-driven service mindset, and simplified protocols via ProdromeScan/Biometrics for monitoring progress toward longevity escape velocity.
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Continuing part two with Dr. Dayan Goodenowe on lipid biology, plasmalogens, and neurodegenerative prodromes. Listen to episode 230 part one first for foundation. Jumping into chronic illness and neurodegenerative prodromes through Goodenowe lens.
Discussing chronic illness and neurodegenerative prodromes, patterns from lab testing, root causes, and support approaches including plasmalogen precursors, phospholipids. Question: How similar or dissimilar are modern chronic diseases like autism spectrum, PANS/PANDAS, chronic Lyme, mold illness, Alzheimer's, MS, Parkinson's? Environment drives via toxicity, non-native EMFs, terrain disruption, chronic infections, immune dysregulation, poor food quality, nutrient density, air/water quality, stress.
Dr. Goodenowe: More similarities than differences. Human body designed to work unless born with severe genetic metabolic disorder; these are acquired. Not attacked by external pathogen; philosophical fault to seek protagonist. No child born with autism—neurodevelopmental delay from reduced health. MS, Parkinson's, ALS, dementia are loss of function from failure to maintain health. Similar stresses proliferate diseases like canary in coal mine; what breaks varies by individual.
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