EP230: Lipid Biology, Plasmalogens, and Neurodegenerative Prodromes - Part 1 - Dayan Goodenowe, PhD
In a Nutshell
Dr. Dayan Goodenowe explains that plasmalogen deficiencies in cell membranes, driven by peroxisomal dysfunction and oxidative stress, underlie neurodegeneration, inflammation, and chronic diseases like autism, dementia, and heart disease. His patented alkyl-acyl glycerol precursors—Plasmalogen N3 (DHA/omega-3 for vitality, cognition, and reverse cholesterol transport) and N9 (omega-9 for structure, myelination, and calming neuroinflammation)—bypass gut breakdown, restore membrane fluidity and antioxidant capacity, and outperform dietary plasmalogens. Optimal use involves N9 first for sensitive cases (night dosing), N3 mornings, alongside mitochondrial supports (NAC, thiamine, fasting) and animal-sourced PC-plus products; monitor via blood plasmalogens, HDL >50, triglycerides <100.
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Episode 230 features Dr. Dayan Goodenowe, neuroscientist, biochemist, inventor, and clinical research expert. In 1999, invented and patented ion cyclotron resonance mass spectrometry for comprehensive human biochemistry monitoring. Analyzed blood from tens of thousands of individuals across ages, races, countries. Compared healthy vs. diseased biochemistry in over 20 conditions: autism, dementia, colon cancer, heart disease, others. Examined age-related differences and all-cause mortality associations. Identified early biochemical patterns for disease and mortality risk, leading to patent portfolio for diagnostics in cancers, neurological disorders, psychiatric conditions, cardiovascular disease. Author of Breaking Alzheimer's, documenting research on neurodegeneration and lipid biology.
Part 1 covers lipid biology and plasmalogens; Part 2 (Episode 231) dives deeper into neurodegenerative prodromes. First guest on relaunched Better Health Guy podcast. Previously discussed in Episode 186.
Body has ~30 trillion structural cells plus ~30 trillion gut microbiome cells. Cellular membranes provide biological structure via phospholipid bilayer. Phospholipids have hydrophilic polar head and hydrophobic lipophilic fatty acid chains that self-organize into walls separating cells.
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