Back to Sean OMara, MD JD, Health & Performance Optimizing

I tested GLP-1s for 30 days (honest results)

In a Nutshell

Your body produces natural GLP-1 in short 2-minute pulses that your gut microbiome and L-cells regulate perfectly, while injected versions stay constantly active for days or weeks and bypass this system. Visceral fat blocks both your production and receptor function of GLP-1, creating a disease cycle that synthetic drugs mask rather than fix. To transition off the drugs, eliminate visceral fat through MRI monitoring, eat fermented foods daily, cut processed foods, and gradually reduce medication as your body restores its own GLP-1 production.

AI-Generated Notes

These notes were generated by AI and may contain inaccuracies.

Your body makes GLP on its own. It always has. And the version your body makes lasts only about 2 minutes before it shuts it completely off. The one you inject, that you're buying, stays in you for days, sometimes weeks, always on.

The injections work, I'll say that plainly. I'm not here to tell you the drug doesn't do nothing. It does real things. It increases your ability to be satisfied, reduces blood sugar, reduces fatty liver, even sleep apnea and joint pain get better. But nature had every chance to build a hormone that stays switched on, and it didn't. I've spent years asking why that was the case, and I think that's the question that actually matters here.

GLP is a very powerful substance that your body makes. Big pharma has picked up on all these benefits, and they're now creating commercialized products to be able to provide some benefit to your body. That's why it does have benefits. It truly does have benefit. But people are talking about it because of those benefits, and not enough attention is being paid about maybe the compromise associated with it.

Your body is like a supercomputer, though. It has the ability through its metabolism to cleave off these amino acids in certain sequences to produce desirable outcomes. And what's regulating that is your microbiome, your collection of microbes inside of your gut. And that is where big pharma never can compete with. The collection of organisms, different bacteria, fungi, yeast, archaea, different forms of life, and what they're producing, the ecosystem down there. Think the fertilizer in the soil. They can't really reproduce that, but the better your microbiome is, the better you can cleave those amino acids off of molecules of protein that you get when you eat healthy foods. So, think your microbiome as having a central role in all of this.

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