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OpenAI Misses Targets, Codex vs Claude, Elon vs Sam Trial, Big Hyperscaler Beats, Peptide Craze

All-In PodcastMay 1, 20261h 20m
In a Nutshell

OpenAI missed ChatGPT user and revenue targets amid compute shortages and Elon's lawsuit alleging breach of charitable trust, but GPT-5.5 excels in coding and cyber defense, outpacing Anthropic's buggy Opus while hyperscalers like Google, Microsoft, Amazon, and Meta dominate with $725B 2026 capex for AI infrastructure. AI drives massive productivity via tokens and agents (requiring supervision to avoid disasters like database deletions), cyber evolves to machine-vs-machine equilibrium, and big tech earnings signal a shift from free cash flow to asset-heavy builds. Retatrutide's phase 3 data shows 37lb weight loss with metabolic benefits, fueling peptide hype, as Bayer fights Supreme Court case on Roundup labeling preemption.

AI-Generated Notes

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Jason shares clip from Miss Thing podcast's 'Gay Name Straight Name' bit. For David: straight name but has perfect body like Michelangelo's David. For Chamath: gay name, Italian sweater at gay poker nights, talks about wine, gym selfies.

Gay Name or Straight Name. David. David to me is straight. Okay. But he has my perfect body... Like the Michelangelo's David, the male ideal. It's like incredible body, kind of small.

Gay Name or Straight Name. Chamath... gay. I feel like Italian. Italian sweater... wears it to like poker night... gay poker nights... Always talking about wine... swishing... guy at the gym taking off his shirt, taking selfies.

Shoutout to Miss Thing Podcast. Open sourced 'let your winners ride, I'm going all in' to fans.

Hosts: David Friedberg, Chamath Palihapitiya, David Sacks, Jason Calacanis (JCal).

OpenAI missed 1 billion weekly active users (1% of world) target for end of 2025; still not hit 4 months into 2026 (WSJ). Missed 2025 ChatGPT revenue target; current run rate $20-30B (accounting nuances).

$600B valuation equals $10B spending commitments for compute. CFO Sarah Friar worried revenue not growing fast enough; OpenAI wants 2026 IPO but Friar says not ready for public reporting. Tension with Altman; joint statement released.

Sacks' Contrarian Take

Bad week in press: missed user/revenue targets, data center commitments questioned, Elon lawsuit. But product strong: released ChatGPT 5.5, strong reviews from developers/coders. Anthropic Opus 4.7 bust: complaints, rolling back to 4.6, rationing compute, reducing thinking time, bugs.

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