Episode #224: Nitric Oxide with Beth Shirley, RPh, CCN
In a Nutshell
Nitric oxide (NO) is essential for circulation, immune function, hormone balance, brain health, fertility, and preventing clots, with production dropping sharply after age 40 due to diet, stress, medications, genetics (e.g., MTHFR), glyphosate, and post-viral/vax damage; prioritize the safe nitrate-nitrite-NO pathway (via arugula, beets, celery, or oxalate-free supplements like 320mg nitrate capsules) over risky L-arginine/NOS pathway to recouple eNOS, reduce superoxide/oxidative stress, support BH4/methylation, lower blood pressure/inflammation, improve ED/POTS/diabetes/kidney function, and enhance all therapies. Daily dosing: 2 capsules AM + nitrate-rich veggies; test salivary strips to confirm levels; pair with antioxidants like vitamin C/melatonin; avoid mouthwash/antibiotics disrupting oral microbiome conversion. NO deficiency underlies most chronic diseases—optimize as protocol base for microcirculation, mitochondrial ATP, BDNF/neurogenesis, and stem cell efficacy.
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Welcome to Better Health Guy Blogcasts, empowering your better health. The content is for informational purposes only and is not intended to diagnose, treat, or cure any illness or medical condition. Nothing in today's discussion is meant to serve as medical advice or as information to facilitate self-treatment. Always discuss health-related decisions with your personal medical authority.
Beth Shirley, RPh, CCN, developed expertise as a compounding pharmacist and board-certified clinical nutritionist over 40 years. Pioneer in integrative pharmacy, junction between traditional pharmacy and clinical use of nutritional supplementation. Since 2009, worked with leading nitric oxide researchers, gaining in-depth knowledge and applications in patient care. Collaborated with scientific community and companies on innovative nutritional ingredients. Formulated product awarded first patent on supplement to increase sexual desire and pleasure. Currently director of education and research for Approved Medical Solutions, distributor of her oxalate-free nitrate product and Libby line of women's wellness products.
Became pharmacist to help people. After 20 years seeing patients return sicker on more drugs, became certified clinical nutritionist in 1997. Known as pharmacist for getting off drugs. Integrative pharmacy near first nitric oxide company, Neo40. Before Neo40 launch, they were clients in 2009. Helped develop L-SEP (likely LSE), released in 2010 as one of first specific nitric oxide products.
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