Everything You Didn't Know About Reproductive Longevity
In a Nutshell
Dr. Jennifer Garrison outlines the Buck Institute's moonshot to end menopause by addressing ovarian aging, which accelerates twice as fast as the body, triggers cascading health declines (e.g., heart disease, cognitive impairment, osteoporosis), and correlates with overall lifespan—later menopause extends life for women and their male relatives. Women's eggs plummet from 7 million in utero to ~2% by age 40, driving menopause around 52; current fixes like IVF, egg freezing, and HRT are invasive band-aids, while underfunded research targets oocyte mitochondria, inflammation, and brain-ovary signaling for interventions like NMN. Join OVA membership at ovabuckinstitute.org to fund diagnostics, biomarkers, Evvatar models, and global efforts aiming to maintain 20s-like ovarian function lifelong, slashing $600B+ annual economic costs from menopause affecting 1B+ women by 2025.
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Welcome to June webinar on reproductive longevity with Dr. Jennifer Garrison from the Buck Institute for Research on Aging in the Bay Area, led by Dr. Eric Verdin. Buck Institute is the leading institution in longevity. Longevity Platinum trip run by Claire Adair featured work on women's reproductive longevity.
Dr. Garrison is faculty director of the Global Consortium for Female Reproductive Longevity and Equality, assistant professor at Buck, associate director of Buck-USC Biology of Aging PhD program, with secondary appointments at UCSF and Leonard Davis School of Gerontology at USC.
Buck launched moonshot to solve female reproductive aging. Aging is public health pandemic; age is number one risk factor for every disease of modern world. Biological age is malleable; aging can be slowed, stopped, or reversed. Modern medicine ignored age as therapeutic target until recent basic science discoveries.
Extending healthy longevity requires equality; interventions must be available to all. Without addressing reproductive longevity, gender inequality worsens. Women's reproductive span influences every aspect of life from puberty: health, family planning, career.
Menopause is literally the worst thing that can happen to a woman's body.
In healthy women, menopause triggers cascade of negative health effects: increased risk of cognitive decline, heart disease, stroke, depression, osteoporosis, arthritis.
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