Harvard Prof Reveals Age-Reversing Science to Look & Feel Younger w/ David Sinclair
In a Nutshell
Harvard professor David Sinclair reveals epigenetic reprogramming using Yamanaka genes resets cellular age, reversing aging in mice, monkeys, and soon humans via eye injections (Life Biosciences trials January 2025) and AI-designed cheap pills (4 weeks to rejuvenate). Information theory of aging posits epigenome noise, not wear-and-tear, drives decline; sirtuins prioritize DNA repair over maintenance as NAD drops, but reprogramming restores youth, cures diseases like blindness, ALS, and potentially cancer by rebooting self-healing. Longevity escape velocity by 2030s promises doubled lifespans; Sinclair's protocol includes NMN (1g), plant-based diet, exercise, sauna, fisetin, and pulsed rapamycin, urging donations amid funding cuts for trillion-dollar healthspan gains.
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Have we reached age reversal technology that truly works? Imagine in 10 years taking a pill for 4 weeks to get younger. Why do we age? The epigenome is the issue because going through sperm, egg, and fertilization resets the epigenome. We've figured out a way to safely reset it without cloning yourself.
We've gone from supplements or exercise to slow aging to truly resetting the body and all cells to be young again. Teenagers today will live into the 22nd century.
Welcome to Moonshots episode on age reversal, focusing on longevity, epigenetic reprogramming, longevity escape velocity, and AI's role. Guest: Dr. David Sinclair, Harvard Medical School professor, author of Lifespan. Discuss near-term developments, support, involvement, benefits. At age 55, David looks 35. We're living in extraordinary times for additional decades of life.
David, welcome. Good to have you back. More focused on health than ever. Muscle mass and exercise remain primary pro-longevity interventions. Eating right, sleep, diet only go so far. Can we turn back the clock?
10 years from now, 2035: state of age reversal technology? Best guess: In Lifespan, predicted wearables, video conferences with doctors, online medicines in 15 years; happened in 3. Sometimes underestimate pace.
Sitting on front row of future. Pace of change is remarkable, head-spinning. 2017: theory to reverse aging. Proved and published in 2020: reverse most aspects of aging by reprogramming cells. Changes everything.
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