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How Genes Shape Your Risk Taking & Morals | Dr. Kathryn Paige Harden

Andrew HubermanFebruary 9, 20262h 42m
Topics39
Podcast Introduction0:31Episode Topics1:00Dr. Harden's Expertise and Book1:30Podcast Disclaimer and Start2:01Defining Adolescence4:31Personal Puberty Experiences and Variation6:00Puberty, Aging, and Personal Reflection11:30Sponsors14:01Environmental Cues and Puberty Onset16:30Communicating Sensitive Topics19:00Hypothalamus and Seven Deadly Sins22:00Genetic Overlaps in Risky Behaviors and Disorders26:17Cultural Fears of Genetic Origins51:55Talking About Genetics and Identity52:01Developmental Origins of Antisocial Behavior55:30Dogs vs. Humans: Responsibility and Inherent Badness59:31Charles Whitman Case1:04:32Dutch Family MAOA Mutation1:07:32Empathy Shifts to Victims1:10:30The Rescue-Blame Trap in Morality1:19:30Bad Seed Hypothesis and Cycle Breaking1:21:01Genetics, Recombination, and Novel Children1:23:01Belief in Inherent Goodness and Scientific Hierarchies1:27:00Traits of Successful Entrepreneurs and Thought Experiment1:32:03Sex Differences in Aggression and Conflict1:36:31Sensation Seeking and Impulse Control Maturation1:43:02Punishment and Rewarding Good Behavior1:45:01Psychology's Dark and Light Sides and Punishment1:45:18Sponsor: Helix Sleep1:51:30Modern Accountability, Cancel Culture, and Public Examples1:53:01Evolutionary Perspectives on Punishment and Reward2:00:01Retribution, Victimhood, and Power Dynamics2:12:20Reward Sensitivity and Freeloading2:16:31Modern Society, Online Dynamics, and Local Action2:25:01Audience Q&A: Twins, Genetics, Environment2:30:30Closing Remarks and Book Promotion2:39:15Podcast Support and Subscriptions2:40:01Andrew Huberman's New Book2:40:33Social Media and Newsletter2:41:00
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There is a reward visible in the brain when people see someone suffer if that person is portrayed as a wrongdoer. Normally, seeing someone shocked activates the anterior insula, as if you are being shocked. But if the person violated a moral or social norm, dopamine release occurs, providing reward from seeing them punished. This is a lust, similar to lust for substances or sexual partners—a desire to see people punished.

Welcome to the Huberman Lab podcast, discussing science and science-based tools for everyday life. Andrew Huberman is a professor of neurobiology and ophthalmology at Stanford School of Medicine. Guest is Dr. Kathryn Paige Harden, psychologist and geneticist, professor at University of Texas at Austin. She studies how genes shape life trajectories, interacting with adolescent life events to impact long-term mental and physical health.

Discussion covers nature-nurture interplay in addiction, criminality, trauma susceptibility, and themes of sin, sociopathy, empathy, forgiveness. Dr. Harden defines how biology, psychology, and life's randomness drive choices. Topics include male-female differences, hormones, hormone-independent influences, and role assumptions based on power structures. Direct conversation on genes, environment, biology (genes, neurotransmitters, hormones) driving available choices and tendencies.

Dr. Harden researches with exceptional rigor. She is clear, direct, compassionate, believes in self-improvement regardless of genes, and improving the world, all backed by data. New book: Original Sin: On the Genetics of Vice, the Problems with Blame and the Future of Forgiveness, available for pre-sale anywhere books are sold.

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