My Current Longevity Stack
In a Nutshell
The speaker's longevity stack emphasizes basics—sleep, exercise, healthy eating—plus vitamin D, creatine, intermittent fasting (with occasional 3-7 day fasts for autophagy), and cautious experiments like ketone esters/salts for brain health, urolithin for mitochondria, and pulsed rapamycin combined with interval training. He avoids unproven interventions using a "no biological free lunch" heuristic, while exploring "system reboots" such as stellate ganglion blocks, photobiomodulation, GLP-1 agonists, and ibogaine (noting its brain age reversal potential via GDNF in TBI studies). Bullish on brain stimulation and bioelectric medicine for psychiatric and performance gains, with future interest in rapamycin, eye drops, and neurosensory/cosmetic aging fixes.
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Recalls attending the first quantified self meetup in 2008 at Kevin Kelly's house with 12 people discussing measuring things with Excel spreadsheets. Notes the world has changed with armies of tens of thousands of self-described biohackers talking about longevity, much of it nonsense.
Guest's Current Stack: Focuses on basics that matter: sleep well, exercise a lot, eat well. Takes one or two helpful supplements. Waiting for real drugs that impinge on longevity. Interested in experimenting with rapamycin or similar.
Future Interests: Eye drops for aging-related lens muscle weakening affecting focus. Neurosensory aging interventions worth funding a startup for. Cosmetics of aging: funded a clinical trial at Stanford; invested in peptides like 5HKCU and melatonin, which are cosmetic in nature.
Short List: Vitamin D and creatine.
More conservative than expected. Experimented with many things earlier, including first-generation Dexcom continuous glucose monitors in 2008-2009, unpleasant to wear, no non-type 1 diabetics using them at the time. Avoided questionable gene therapy like fist statin abroad.
Heuristic: No biological free lunch—simplistic but avoids pitfalls.
Current Experiments:
- Different forms of ketone esters and salts for cerebral vasculature, given family history of Alzheimer's, Parkinson's, and APOE4 risk.
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