David Sinclair on the Longevity Pill, Age Reversal Timelines, and Updated Protocols | EP #249
In a Nutshell
David Sinclair announces the imminent first human trial of epigenetic reprogramming using OSK genes (a safe Yamanaka subset) to reverse blindness in the eye, with body-wide benefits shown in every tissue—brain, muscle, kidney, immune system, joints—positioning it as a true longevity therapeutic starting tissue-by-tissue before systemic delivery. Small-molecule alternatives, screened via AI, reverse 92-year-old skin cells to 20-year-old states and enter trials soon at ~$200/month scalability. His updated protocols: resveratrol (with fat for absorption), NMN, metformin/berberine for glucose control, nattokinase (8-10k units) for plaque reversal; mostly vegan diet, no daily alcohol, stress reduction via meditation/relationships, 3 cups coffee/tea daily. Age reversal in humans possible by 2026, no biological lifespan limit.
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This feels like another Wright brothers moment. Once you can fly, everything changes. We're about to learn whether we can fly. We're days away from the first human epigenetic reprogramming trial using three of the Yamanaka genes, a subset, going into the eye of a patient to cure blindness. Every tissue shows benefits: brain age reversal, improvement in memory, motor neurons for ALS, immune system, muscle, kidney, liver, skin. A true longevity therapeutic works throughout the entire body.
Is there an upper limit to how long humans can live? I'm not saying that, but I am saying that.
David drinks coffee, about three cups a day. Studies show caffeine and decaffeinated coffee are good due to other molecules. Coffee is currently in positive fashion for longevity. It's a good way to start the day. Caffeine is fine. David and Serena drink tea all day until they can't take more caffeine.
Drug candidate from David's lab published in 2020 on the cover of Nature magazine titled "Turning Back Time." Student Wangloo found three genes (OSK, subset of Yamanaka genes) that safely reverse aging without causing cancer or loss of cell identity. Yamanaka genes make stem cells, but full set kills mice in 2 days. OSK going into human eye shortly to cure blindness after success in mice and monkeys. Investors in Life Biosciences excited about reversing blindness.
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