Restore Youthfulness & Vitality to the Aging Brain & Body | Dr. Tony Wyss-Coray

Parabiosis Experiment: Young Blood Rejuvenates Old Brain00:00

For the first time we could take an old brain and give factors from a young organism and ask is that going to change the age of the brain and that's indeed what it did. Stem cells in the brain of these mice got reactivated, there was less inflammation, more activity that we can measure in the brain, and most importantly their memory function improved.

Welcome to the Huberman Lab podcast where we discuss science and science-based tools for everyday life. I'm Andrew Huberman, professor of neurobiology and ophthalmology at Stanford School of Medicine. My guest today is Dr. Tony Wyss-Coray, professor of neurology at Stanford School of Medicine and expert in identifying factors that can help prevent and reverse organ aging.

Introduction to Young Blood and Exercise Factors00:31

Today we discuss factors present in young blood and factors present in blood after exercise that have been shown to rejuvenate the brain and other tissues in older individuals. Dr. Wyss-Coray's lab discovered several proteins present in high amounts when young that circulate in the blood, diminish with age, and if supplied to the aged body and brain can reverse key features of aging including improved cognition, tissue recovery from stress, damage and more.

Nonlinear Aging and Organ-Specific Clocks01:00

Aging is nonlinear, does not progress uniformly across the lifespan. Certain phases such as puberty, early 40s, and early 60s feature accelerated aging that then slows again. Different organs age at different rates and you can measure that.