"I've Had Some Wild Peptide Experiences" - Andrew Huberman
In a Nutshell
Huberman injected BPC-157 directly into his shoulder and eliminated chronic pain from heavy lifting, with similar mobility improvements reported in elderly dogs. He achieved 2.5-3 hours of REM sleep using low-dose epitalon, while growth hormone stimulators disrupted his sleep and raised PSA. Clinical trials combining MDMA and psilocybin successfully decoupled negative emotions from traumatic experiences, unlike either substance alone.
These notes were generated by AI and may contain inaccuracies.
Andrew Huberman discusses protocols he believes in but cannot prove scientifically. He notes these experiences are not covered in his book since they lack supporting mechanisms and explanations.
Huberman describes a personal experiment with BPC-157 after developing shoulder pain from resuming heavy push-ups, parallel bar dips, and upper shoulder presses. He began experiencing shoulder pain after 2-3 months of this routine. After trying rotation exercises without relief, he injected two BPC substances - 100 or 200 micrograms each - directly into the affected area. The pain completely disappeared. He acknowledges this could be a placebo effect but notes he knew what he was injecting. Animal data shows impressive results, particularly for tendon repair in rats and mice. Huberman knows multiple people who inject BPC-157 into their elderly dogs suffering from spinal cord strokes or age-related mobility issues, with owners reporting significantly improved mobility.
Huberman tested epitalon (also called epithalamin), a peptide from brain tissue rather than the pineal gland. He took approximately one-tenth of an international unit every third or fourth night, achieving 2.5 to 3 hours of REM sleep within 6-7 hours total sleep time. This is notable because rich REM sleep typically occurs in the final third of a 7-8 hour sleep cycle. The increased REM effect continued on subsequent nights even after reducing frequency to once weekly or once every ten days. The main downside is feeling somewhat sleepy the next day despite maintained concentration. Some people use it during the day for cognitive work in a state of sleep and superficial wakefulness.
Huberman states he is not a fan of growth hormone stimulators like tesamorelin, ipamorelin, and CJC-1295. These compounds have consistently disrupted his REM sleep and elevated his PSA levels. At age 51, he feels he is still in good position and does not see compelling reason to experiment with somatotropic growth hormone. He acknowledges data exists for low-dose growth hormone in older populations but notes this would be outsourced in clinical trials.
Huberman has participated in legal clinical trials combining MDMA and psilocybin for treating PTSD and depression. He emphasizes these must be conducted in proper clinical settings with pre-treatment, during-treatment, and post-treatment support services. Psilocybin alone was helpful but did not fully resolve certain issues. MDMA helped with sensing and acknowledging emotions as initial steps. The combination therapy allowed decoupling negative feelings from negative experiences and replacing them with positive feelings - an effect he had not achieved with either substance alone. He notes limited data exists on the multipharmacology of combining these substances, and FDA approval has not yet been granted for combination approaches.
Huberman discusses ibogaine, noting conversations with people who report positive effects, though he has been advised against traveling to Mexico for treatment. He distinguishes between those with drug problems versus those with PTSD. He expresses concern about DMT due to the requirement for consecutive daily dosing and has observed that while some people use it without issues, others become genuinely eccentric compared to their previous personalities. He references a podcast guest who found benefit from DMT when starting from a very low baseline situation involving suicidal ideation.
Huberman promotes Momentous supplements, noting co-founder Jeff Byers' NFL background and the company's focus on evidence-backed ingredients, transparent dosages, and third-party testing. All products are NSF certified for sports. The company offers a 30-day money-back guarantee and international shipping, with up to 35% off first subscriptions using code "modernwisdom" at livemomentous.com/modernwisdom.
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