Welcome to our live show!
These notes were generated by AI and may contain inaccuracies.
Alpha Maker bi-weekly event broadcast today. Internal participants can ask questions in chat. Posting links to join Alpha Maker, special promotion Alphamaker Patriots for public servants.
Sean takes over: Proud of AlphaMaker community, sharing unique science and Q&A. First half covers science on alcohol use disorder (technical term for alcoholism) and innovative treatments.
Encourages joining AlphaMaker community to end chronic disease. Links: growingbetternotolder.com/alphamaker (standard subscription). For military, former military, government, first responders: growingbetternotolder.com/alphamakerpatriot (90% off).
Emergency medicine physician story from 15 years ago: ER nurse's identical twin uncles (monozygotic, fertilized egg split). One profound alcoholic, lifelong tragedy, multiple failed quit attempts; other twin abstained completely. Alcoholic uncle had end-stage alcohol use disorder, cirrhotic liver, hepatic encephalopathy—talking into electric razor due to confusion. Needed liver transplant; twin brother refused partial liver donation, knowing he'd continue drinking and destroy it. Haunting story, especially as speaker is identical twin.
Randomized controlled trial in Hepatology 2021: FMT (stool from healthy donor into diseased person) reduces craving, inflammation, relapse in alcohol use disorder, proving microbes influence willpower via gut-liver-brain axis and endotoxemia (gut toxins in bloodstream). Reprograms biology for freedom from compulsion (alcohol, drugs, pornography, gambling, sexual offenses).
FMT started ~2009; best treatment for C. diff (150,000 US deaths/year).
Connects to AlphaMaker protocols for microbiome optimization; potential to serve as paid stool donor (one made $250,000 part-time). Speaker's practice exploring living biologic product (LBP) akin to FMT.
Hepatology 2021 RCT: Participants with alcohol use disorder and cirrhosis. Single donor fecal microbiota enema enriched with Lactobacillus rhamnosus and Ruminococcus species. Reduced cravings 90% (vs 30% placebo). Decreased alcohol consumption (measured by EtG metabolite). Improved cognitive performance, quality of life.
Speaker's tragedies: 25-year-old with alcohol-induced myocarditis died post-hospitalization due to continued drinking; no transplant for active drinkers (tested via EtG).
Nature Communications 2022: Reduced alcohol preference/intake transmissible to germ-free mice via FMT (after antibiotics/diuretic to clear microbiome, like colonoscopy prep).
FMT restores gut-liver-brain axis disrupted by ethanol; reduces craving/intake, improves cognition/mood; restores microbial metabolites like butyrate (short-chain fatty acid regulating inflammation, neuro-signaling).
Gut epithelial integrity restored (prevents leaky gut, endotoxemia). Toxins blocked from portal vein to liver (reduces IL-6, TNF, cirrhosis, hepatitis). Short-chain fatty acids modulate brain GABA/glutamate, reward centers. Immune biomarkers normalized via butyrate.
Microbiome as master regulator of craving, cognition, control.
Optimizing microbiome essential for health. AlphaMaker covers it deeply (e.g., Ultimate Start: MRI for visceral/heart fat, 6 big strategies + 44 more in year-long program).
Lactobacillus rhamnosus GG (LGG): Prevents liver fibrosis (inhibits hepatic bile acid synthesis, enhances excretion) in mice. American Journal of Gastroenterology 2023 RCT: Double-blind, reduced cravings and hepatic inflammation in moderate alcohol-associated hepatitis.
Available on Amazon; recommend for alcohol issues.
Other studies: Probiotics restore bowel flora, improve liver enzymes in alcohol-induced liver injury.
Doctors horrified twin refused liver donation, but likely right—surgeries risky, recipient would relapse. Real solution: fecal microbiota transplant from healthy twin's stool.
Challenge notion of alcoholism as moral failing; it's biology needing interventions like probiotics/FMT.
Alcoholics are infected with microbes in their microbiome that drive alcohol consumption and cravings. Species of microbes dependent on alcohol exist inside the gut, totaling 70 trillion microbes. Science is just starting to learn about them. Push the narrative to expedite treatments like insights into this disease. Many view alcoholism as a moral failing or poor judgment, but it is a biological condition. Fecal Microbiota Transplants (FMTs) can deliver relief. Physicians can't do this alone; grassroots efforts from patients and politicians are needed. Big Pharma won't support it because FMTs cure many conditions beyond alcoholism and substance abuse, including gambling, pornography addiction, Crohn's disease, inflammatory bowel disease, depression, anxiety, and even cancer.
Exciting studies show FMTs reversing these conditions. The speaker is excited to take a serious role with an upcoming company focused on this. For loved ones with alcohol use disorder, message Alvo for opinions and connections.
Alvaro hosts the AMA; submit questions in comments on social platforms.
Lord's, 45 years old, does weights three times a week. Asks if sprints on a trampoline are okay due to flat feet; hard to run on grass or asphalt.
First, six key optimization strategies for the microbiome:
- Eat meat.
- Eat fermented foods, chewed with meat to add living microbes. Alphas intersperse microbes in the mouth; digestion begins ideally. Carnivores eating just meat or vegans just plants seed bad microbes, leading to disease.
- Sunshine: Strip down, no sunscreen, maximize exposure within reason. If starting to burn, use white clothing, not sunscreen.
- Heat: Dry Finnish sauna, not infrared.
- Cold: Cold showers or plunging for hormesis.
- Sprinting or fighting: Intense, short bursts (fight or flight). Fights in nature end fast, not prolonged like jogging or pro boxing.
Answer: Do not recommend sprinting on a treadmill—unnatural moving surface increases injury risk, especially with age and visceral fat impairing recovery. Safest for beginners: sprint up an incline like a hill or parking garage ramp. Less likely to pull muscles, strain, or tear tendons. Treadmills are dangerous; people fall off, hit heads, and die. Speaker has a patent on a treadmill device.
Down from 195 to 175 pounds since August 2024, now 180; gyms three times a week.
Get an MRI scan to see visceral fat around heart and abdomen—this motivates seriousness. Many long-term carnivores (up to nine years) still have visceral fat. Add living microbes to meat (living carnivore diet) to optimize microbiome; without it, disbiosis prevents fat mobilization, causing yo-yo dieting and plateaus. Do all optimization strategies. Visit practice for Ultimate Start program (includes MRI), two-month program, or see doctors in Minneapolis or Naples, Florida.
Extended fasting, not just intermittent. Ancestors fasted days/weeks between hunts. Alphas fast at least two days a week, often three; speaker does 72 hours (three days) one week, 96 hours (four days) the next. Everyone can do it genetically, but ease in over 3-6 months to overcome carb dependence. Ultimate Start program guides this.
Shoutout to new Patriot sign-up: Back on carnivore almost 60 days.
Diverticulitis is inflammation of diverticula (herniations in colon wall). Visceral fat weakens colon muscle, causing ballooning like a hernia. ~20% of clients have it; can rupture and kill. Surrounding visceral fat causes inflammation. Fill colon with beneficial bacteria via fermented foods, fasting, sunshine to reduce pathogenic ones. Avoid processed foods, carbs, sweets that feed bad microbes (like feeding bears). Get abdominal scan. Example MRI: Beautiful colon surrounded by white visceral fat; also fat around heart, liver, lungs, abdomen. Governor Stitt (first U.S. governor scanned for visceral fat, encouraged by Secretary Kennedy) is reducing his.
Shoutouts to Janice and others from Queensland, Australia; Vivec from India.
Quick burst "exercise snacks" several times a day as alternative? Higher carb burning in first minutes of cardio?
Sprinting burns more calories short-term, produces more myokines (exercise signaling molecules) than jogging, aerobic exercise, yoga. Intense short bursts best. Long-duration exercise produces excess reactive oxygen species, leading to visceral fat/heart fat. Distance runners look skinny outside but have internal "invisible obesity." Best exercise: Intense, brief, recover—like other species. Build fast-twitch muscles for longevity (getting out of chair at 90-120 years old), not slow-twitch from marathons.
Histamine intolerance causes runny nose, congestion, malaise, fatigue, nausea, bloating. Present in fermented and non-fermented foods, higher in fermented. Watch speaker's YouTube video: "Dr. Sean O'Mara, histamine" for explanation and guidance. Do not avoid fermented foods—they improve microbiome and quality of life. Cut back, colonize gut with microbes first. Hundreds/thousands cured via these tactics.
Visceral fat comes first, starting in childhood (e.g., pancakes, waffles, sugary cereals, pizza, bread, muffins, donuts). Insulin resistance, metabolic syndrome downstream. Speaker reads visceral fat in faces at conferences. Examples: Two brothers (8 and 10 years old) transformed in six months—average to model-like, bigger red lips from better blood flow/oxygen. Raise kids (not babies) on living carnivore diet (meat + ferments). Speaker's boys grew up optimized this way.
Do not sprint with any injury or pain (e.g., Achilles tendinitis). Too many forces; risk tearing/strain, creating lifelong vulnerability. Recover fully. In emergencies (fire), need full sprint ability.
Thanks to all. Post questions on growingbetternotolder.com; sign up for 5-3 elimination biohack diet. Links available.
Keep Sean OMara, MD JD, Health & Performance Optimizing in your library
Save the videos and channels worth coming back to, and find them again in one place.
