Bryan Johnson: I Just Took the Most Powerful Dose of DMT in the World... Here's What It Was Like
In a Nutshell
Bryan Johnson describes his intense 5-MeO-DMT experience (9mg IM + 18mg vaporized), the world's most powerful psychedelic, as an ego-dissolving reset of consciousness that annihilated the default mode network, induced unimaginable bliss upon surrender, and restored childlike joy, openness, and conflict resolution—far surpassing psilocybin's effects. He frames it as a longevity breakthrough, enhancing neuroplasticity, reducing inflammation, and providing psychological rejuvenation unmatched by diet, exercise, or sleep, with post-trip brain scans showing youthful patterns. Future plans include mitochondrial therapy, FOXO3 plasmids, and organoids from his iPSCs to push biological age reversal, positioning psychedelics as essential for mental youthfulness amid emerging cell/gene therapies.
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Brian Johnson took 5-MeO-DMT, the most powerful psychedelic on the planet, 5-10 times more powerful than DMT. It's been 48 hours, and he's still learning how to talk about it.
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Primarily as a longevity experiment. His project started 5 years ago: reviewed all scientific evidence on health and longevity, prioritized interventions by effect size—exercise, nutrition, sleep, hyperbaric oxygen therapy, sauna, rapamycin, metformin. Psychedelics were not on radar; seen as ancient ritual medicines or for depression/anxiety, not anti-aging. Found pre-clinical mouse evidence on psilocybin, conducted world's most studied experiment: three doses at 25 mg psilocybin (clinical/near-hero doses), concluded it's a longevity therapy.
Livestreamed the session; appeared calm. Impossible to fully explain, but: stunned, floored, speechless. Experienced raw consciousness and raw intelligence. Take words, multiply by a thousand, extend to infinite depth, width, dimensions. Hits fast: 9 mg intramuscular + 18 mg vaporized, effects in 10 seconds. Not very visual like DMT (no elves); lock into a space where you either panic (gates of hell opening, existence tearing you to shreds, threatening sanity) or relent completely—release all attachment, preconditions, wants, desires, self, ego, control. Relenting opens unimaginable bliss and euphoria. Most dynamic human experience ever (surpassing accomplishments, marriage, child, overcoming difficulties).
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