Plaque Reversal: Latest Bale-Doneen Recommendations (Ft. Dr. Bale & Dr. Doneen)
In a Nutshell
Plaque growth persists despite optimal cholesterol control because oxidative stress from root causes like insulin resistance, gut dysbiosis, periodontal disease, poor sleep, stress, and pollution transforms artery smooth muscle cells, trapping ApoB-containing particles (LDL, VLDL, remnants) and igniting inflammation. Reversing plaque requires **SOS—Stop Oxidative Stress** through comprehensive management: balanced diet/exercise (antioxidant-boosting), vitamin D optimization, nicotine cessation, hypertension control, psychosocial health, and oral hygiene, stabilizing plaque and preventing heart attacks, strokes, dementia, cancer, and other aging diseases. ApoB predicts risk better than LDL-C alone, but lean mass hyperresponders with high LDL avoid plaque without oxidative stress; imaging (IMT/CTA) and frequent inflammation labs ensure compliance and track reversal.
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People take steps to avoid heart attacks: drop LDL, track APOB or calcium score, clean up diet, start fasting, read studies. Yet plaque still grows even when cholesterol numbers look perfect. Reason: not just cholesterol; inflammation and metabolic dysfunction drive heart disease.
Conversation with Dr. Brad Bale and Dr. Amy Doneen on their new research article. They connect oxidation, insulin resistance, and plaque activity. Discuss how inflammation drives arterial damage, why lowering cholesterol alone is not enough, and reversing plaque. Their clinical work aligns with Prevmed observations. Focus on inflammation, metabolism, lifestyle changes arteries and future.
Bale and Doneen have done decades of work in heart disease prevention.
Host met Bale and Doneen years ago via a friend recommending prevention experts. Worked together, learned a lot. Aging requires managing diet, exercise, sleep.
Growing old's not for sissies. If you're going to age properly, you got to do the work.
Article co-authored with David Vigerust, geneticist and lab technologist, formerly at Vanderbilt. Previous article showed periodontal disease causes vascular disease. Most vascular disease from undiagnosed metabolic disease. New article on inflammation, topic they've discussed for 30 years.
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